Cyrex Labs Gluten & Immune Testing

I am pleased to announce that, here in the UK, we finally have access to Cyrex Labs range of tests.

This includes:

Array 1 Mucosal Gluten Reactivity Panel
Array 2 Intestinal Antigenic Permeability Panel
Array 3 Wheat / Gluten Proteome Reactivity and Autoimmunity
Array 4 Cross Reactivity and Food Sensitivity Panel
Array 5 Multiple Autoimmunity Reactivity Screen
Array 6 Diabetes Autoimmunity Reactivity Screen
Array 7 Neurological Autoimmunity Reactivity Screen
Array 7X Neurological Autoimmunity Reactivity Screen Expanded Panel
Array 8 Joint Autoimmunity Reactivity Panel
Array 11 Chemical Immune Reactivity Screen
Array 20 Blood Brain Barrier

I want to briefly comment on three of these tests.

Array 2 – Intestinal Permeability/Leaky Gut

The test that many of us have been using up till now to assess leaky gut, the lactulose/mannitol test was actually designed to assess malabsorption. Array 2 therefore provides a much more comprehensive and more reliable assessment of an individuals gut lining. Leaky gut has been associated with:

Gluten sensitivity
Food Allergies
Inflammatory Bowel Disease
Numerous Autoimmune Diseases
Neurological Conditions
Cognitive Dysfunction

Array 3

Chris Kresser wrote a great article in The Huffington Post which I going to quote some of:

“Here’s the crucial thing to understand: Celiac disease is characterized by an immune response to a specific epitope of gliadin (alpha-gliadin) and a specific type of transglutaminase (tTG-2). But we now know that people can (and do) react to several other components of wheat and gluten — including other epitopes of gliadin (beta, gamma, omega), glutenin, WGA and deamidated gliadin — as well as other types of transglutaminase, including type 3 (primarily found in the skin) and type 6 (primarily found in the brain).

This is a huge problem because conventional lab testing for CD and of gluten intolerance only screens for antibodies to alpha-gliadin and transglutaminase-2. If you’re reacting to any other fractions of the wheat protein (e.g., beta-gliadin, gamma-gliadin or omega-gliadin), or any other types of transglutaminase (e.g., type 3 or type 6), you’ll test negative for CD and gluten intolerance no matter how severely you’re reacting to wheat.”

It’s also important to note that you may be reacting to gluten have no gastrointestinal symptoms. This is significant – we cannot rely solely on symptoms any more. This is why testing is so important.

Array 4

We also now know that it is possible to cross react. What this means is the immune system may mistake, as an example, casein from cow’s milk as gluten. So, if a coeliac removes gluten from their diet and does not see improvement you may want to investigate cross reactivity.

This is a very brief summary of the tests I feel are most significant. Please do get in touch if you would like to learn more about this service.

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