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Melatonin And Gut Health

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Everything You Need To Know About Mycotoxin Enniatin B

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Psychedelics and Behaviour Change

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Alexithymia: The Role Of Emotions In Health

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Chronic Fatigue

Can Leaky Gut Cause Chronic Fatigue Syndrome (CFS)?

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What Are The Health Benefits Of Cold Exposure?

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Coffee reduces your risk of chronic kidney disease

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Nutritional Status Helps Prevent Alzheimer’s Disease

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The Biohacker Series

What Is Melatonin And Why Is It So Important?

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Optimise Health With Sauna Therapy At Home

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Histamine Intolerance

Do Mycotoxins Cause Histamine Intolerance?

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Supplement Spotlight

Medicinal Mushrooms

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Muscle Sciene

What Is The Gut-Muscle Axis And How Are They Connected?

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Nutritional Therapy

Medicinal Mushrooms

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Behavioural Change

Alexithymia: The Role Of Emotions In Health

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alexandermanos

“Vitamin A is an important micronutrient, from p

“Vitamin A is an important micronutrient, from plants diet taken up as carotenoids, from animal food sources as retinol. Its active metabolite retinoic acid binds to nuclear hormone receptors, thereby regulating gene transcription programs in various cells. Adequate nutritional intake of vitamin A is essential for pre- and postnatal development, eyesight and reproduction, and it contributes to the maintenance and regulation of the immune system.

Recent molecular studies indicate that lipocalins play an important role in the bioavailability of retinoic acid and its immune modulation against Th2 responses.

There is emerging evidence that supply with vitamin A determines the susceptibility to allergic diseases: significantly reduced serum vitamin A levels are commonly observed in allergic patients compared to healthy controls. In line, findings from nutritional and clinical trials suggest that sufficient vitamin A supplementation in pregnancy prevents the development of allergic diseases in the offspring, and helps in controlling symptoms in adult asthmatics.

Overall, retinoids have a key role in regulating immune homeostasis on mucosal surfaces because they are able to interfere with inflammatory signalling pathways.

In this mini-review the authors concentrate on the current knowledge about the influence of dietary and supplementary vitamin A on allergic diseases in humans from infancy to adulthood.”

But we warned, not everyone converts beta-carotene to retinoic acid very well and some of us benefit from consuming animal sources of vitamin A - such as liver, cod liver oil, dairy, and eggs.

PMID: 30339818

“Melatonin exhibits extraordinary diversity in t

“Melatonin exhibits extraordinary diversity in terms of its functions and distribution. When discovered, it was thought to be uniquely of pineal gland origin. Subsequently, melatonin synthesis was identified in a variety of organs and recently it was shown to be produced in the mitochondria. Since mitochondria exist in every cell, with a few exceptions, it means that every vertebrate, invertebrate, and plant cell produces melatonin. The mitochondrial synthesis of melatonin is not photoperiod-dependent, but it may be inducible under conditions of stress. Mitochondria-produced melatonin is not released into the systemic circulation, but rather is used primarily in its cell of origin. Melatonin’s functions in the mitochondria are highly diverse.”

“Our cultural avoidance - and denigration - of o

“Our cultural avoidance - and denigration - of our very human losses and pain creates so many problems, it wouldn’t be a stretch to say we have an epidemic of unspoken grief….it’s important to recognise how pervasive the problem really is. The gag order on pain is everywhere. Everyone has a role to play in overcoming our pain-averse culture.”

From the book ‘It’s ok that you’re not ok’.

L. plantarum 299v is the most documented L. planta

L. plantarum 299v is the most documented L. plantarum strain in the world, described in over 170 scientific publications out of which more than 60 are human clinical studies.

The probiotic strain L. plantarum 299v was isolated from healthy human intestinal mucosa three decades ago by scientists at Lund University, Sweden. Thirty years later, a wealth of data coming from in vitro, animal, and clinical studies exist, showing benefits primarily for gastrointestinal health, such as reduced flatulence and abdominal pain in patients with irritable bowel syndrome (IBS). Moreover, several clinical studies have shown positive effects of L. plantarum 299v on iron absorption and more recently also on iron status. L. plantarum 299v is safe for human consumption and does not confer antibiotic resistance. It survives the harsh conditions of the human gastrointestinal tract, adheres to mannose residues on the intestinal epithelial cells and has in some cases been re-isolated more than ten days after administration ceased.

IBS is the most commonly reported GI disorder globally. Repeated studies have shown that intake of L. plantarum 299v results in decreased severity and intensity of IBS symptoms such as abdominal pain, flatulence, bowel habits and bloating. Moreover, intake of L. plantarum 299v has been shown to increase bacterial diversity in the intestine, provide relief for those suffering from IBD, as well as decrease the incidence of clostridium difficile infection for those prescribed antibiotics.

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